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cemat ist fct

Task 3: Mathematical and numerical study of cerebral aneurysm progression

The main goal of this task (strongly related to tasks 1, 2 and 6) is to develop a geometrical multiscale fluid-structure interaction modeling framework to simulate aneurysm progression from medical images. Integrating and coupling realistic blood flow models with vascular wall models, and by further development of mechano-biologic interaction models will carry this out. We will use this study to investigate the effects of hemodynamics and of different biomechanical interactions on the geometric evolution of aneurysms.

Expected results are:

(1) Non-Newtonian blood flow models and physiological boundary conditions;

(2) Multi-mechanism mechanical models of the vascular wall;

(3) Multiscale fluid-structure interaction models coupling blood flow and wall biomechanics with reduced (1D and 0D) models to account for boundary conditions;

(4) Full geometrical multiscale model implementation of patient-specific aneurysms using 3D real geometries of aneurysms reconstructed from medical images.



Adélia Sequeira; Alexandra Moura; Marco Barbosa; Marília Pires; Paolo Tricerri; Ricardo Pereira; Elias Gudiño Rojas; Alberto Gambaruto (task leader).